Drug interactions
Glipizide + Iloperidone
Severity: Moderate
Glipizide and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics such as iloperidone can cause hyperglycemia and metabolic disturbance, which may counteract glipizide and worsen glycemic control in people with diabetes.
What this interaction means in plain words
Glipizide and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Iloperidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism through antipsychotic-associated impairment of glucose regulation and insulin resistance.
What to do
Monitor fasting glucose and HbA1c after starting iloperidone and increase antidiabetic therapy if control deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Glipizide with Iloperidone?
MediHelp rates the interaction as moderate. Glipizide and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics such as iloperidone can cause hyperglycemia and metabolic disturbance, which may counteract glipizide and worsen glycemic control in people with diabetes.
How serious is the interaction between Glipizide and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting iloperidone and increase antidiabetic therapy if control deteriorates.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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