Drug interactions
Glipizide + Imidapril
Severity: Minor
Glipizide and Imidapril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance insulin sensitivity and can increase the glucose-lowering effect of sulfonylureas. Hypoglycemia has been reported, mainly early in combined therapy or in patients with renal impairment.
What this interaction means in plain words
Glipizide and Imidapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide belongs to Endocrine; Imidapril belongs to Cardiovascular.
Why it happens
ACE inhibition may improve insulin sensitivity, adding to the hypoglycemic effect of glipizide.
What to do
Monitor blood glucose when imidapril is started, especially in elderly patients or those with reduced renal function. Reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Glipizide with Imidapril?
MediHelp rates the interaction as minor. Glipizide and Imidapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors may enhance insulin sensitivity and can increase the glucose-lowering effect of sulfonylureas. Hypoglycemia has been reported, mainly early in combined therapy or in patients with renal impairment.
How serious is the interaction between Glipizide and Imidapril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when imidapril is started, especially in elderly patients or those with reduced renal function. Reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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