Drug interactions
Glipizide + Liraglutide
Severity: Moderate
Glipizide and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liraglutide combined with glipizide increases the risk of hypoglycemia, which can be severe. The effect arises because both drugs promote insulin secretion.
What this interaction means in plain words
Glipizide and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Liraglutide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect of GLP-1 receptor agonism and sulfonylurea-stimulated insulin release.
What to do
Lower the glipizide dose when starting liraglutide and monitor blood glucose closely. Teach the patient to recognize and treat hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Other interactions of Liraglutide
Frequently asked questions
Can I take Glipizide with Liraglutide?
MediHelp rates the interaction as moderate. Glipizide and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liraglutide combined with glipizide increases the risk of hypoglycemia, which can be severe. The effect arises because both drugs promote insulin secretion.
How serious is the interaction between Glipizide and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Lower the glipizide dose when starting liraglutide and monitor blood glucose closely. Teach the patient to recognize and treat hypoglycemia.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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