Drug interactions
Glipizide + Lornoxicam
Severity: Moderate
Glipizide and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as lornoxicam may potentiate the hypoglycemic effect of sulfonylureas, with reports of hypoglycemia. The effect is probably modest, but it can matter in elderly or renally impaired patients.
What this interaction means in plain words
Glipizide and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Lornoxicam belongs to Musculoskeletal.
Why it happens
Possible displacement from protein binding and/or reduced clearance of glipizide; the mechanism is not firmly established.
What to do
Monitor blood glucose when lornoxicam is started or stopped. Adjust the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Other interactions of Lornoxicam
Frequently asked questions
Can I take Glipizide with Lornoxicam?
MediHelp rates the interaction as moderate. Glipizide and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as lornoxicam may potentiate the hypoglycemic effect of sulfonylureas, with reports of hypoglycemia. The effect is probably modest, but it can matter in elderly or renally impaired patients.
How serious is the interaction between Glipizide and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when lornoxicam is started or stopped. Adjust the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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