Drug interactions
Glipizide + Moxifloxacin
Severity: Moderate
Glipizide and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxifloxacin can cause either low or high blood glucose, and patients on sulfonylureas like glipizide are at greater risk of serious hypoglycemia. Severe episodes have occurred with fluoroquinolones in diabetic patients.
What this interaction means in plain words
Glipizide and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones increase insulin secretion through pancreatic beta-cell potassium channel effects, adding to the sulfonylurea.
What to do
Check blood glucose more often during the antibiotic course and counsel on hypoglycemia symptoms. Lower the glipizide dose if hypoglycemia occurs or use another antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Moxifloxacin?
MediHelp rates the interaction as moderate. Glipizide and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxifloxacin can cause either low or high blood glucose, and patients on sulfonylureas like glipizide are at greater risk of serious hypoglycemia. Severe episodes have occurred with fluoroquinolones in diabetic patients.
How serious is the interaction between Glipizide and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more often during the antibiotic course and counsel on hypoglycemia symptoms. Lower the glipizide dose if hypoglycemia occurs or use another antibiotic.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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