Drug interactions
Glipizide + Omeprazole
Severity: Minor
Glipizide and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glipizide is metabolized mainly by CYP2C9, so omeprazole has little expected effect. Any small increase in exposure could marginally raise the risk of hypoglycemia.
What this interaction means in plain words
Glipizide and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide belongs to Endocrine; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Possible weak CYP2C9/CYP2C19 inhibition by omeprazole; not clinically established.
What to do
No dose adjustment needed; monitor blood glucose when starting or stopping omeprazole.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Omeprazole?
MediHelp rates the interaction as minor. Glipizide and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glipizide is metabolized mainly by CYP2C9, so omeprazole has little expected effect. Any small increase in exposure could marginally raise the risk of hypoglycemia.
How serious is the interaction between Glipizide and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment needed; monitor blood glucose when starting or stopping omeprazole.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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