Drug interactions
Glipizide + Voriconazole
Severity: Moderate
Glipizide and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole can increase glipizide exposure, which may cause hypoglycemia. The risk is greater in elderly patients and those with reduced renal or hepatic function.
What this interaction means in plain words
Glipizide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP2C9-mediated metabolism of glipizide.
What to do
Monitor blood glucose frequently and adjust the glipizide dose as needed during and after voriconazole therapy. Instruct patients on recognizing hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Voriconazole?
MediHelp rates the interaction as moderate. Glipizide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole can increase glipizide exposure, which may cause hypoglycemia. The risk is greater in elderly patients and those with reduced renal or hepatic function.
How serious is the interaction between Glipizide and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently and adjust the glipizide dose as needed during and after voriconazole therapy. Instruct patients on recognizing hypoglycemia.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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