Drug interactions
Glofitamab + Mexiletine
Severity: Moderate
Glofitamab and Mexiletine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab causes cytokine release that can transiently suppress CYP enzymes, potentially increasing exposure to mexiletine. Small increases in a narrow-therapeutic-index drug may cause toxicity.
What this interaction means in plain words
Glofitamab and Mexiletine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glofitamab belongs to Oncology; Mexiletine belongs to Cardiovascular.
Why it happens
Cytokine-mediated suppression of hepatic CYP1A2 reduces mexiletine metabolism.
What to do
Monitor for mexiletine toxicity and ECG changes during the first treatment cycles and with cytokine release syndrome. Consider level monitoring and dose adjustment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
Frequently asked questions
Can I take Glofitamab with Mexiletine?
MediHelp rates the interaction as moderate. Glofitamab and Mexiletine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glofitamab causes cytokine release that can transiently suppress CYP enzymes, potentially increasing exposure to mexiletine. Small increases in a narrow-therapeutic-index drug may cause toxicity.
How serious is the interaction between Glofitamab and Mexiletine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mexiletine toxicity and ECG changes during the first treatment cycles and with cytokine release syndrome. Consider level monitoring and dose adjustment.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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