Drug interactions
Glofitamab + Quinidine
Severity: Moderate
Glofitamab and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab induces cytokine release that can transiently suppress CYP450 enzymes. Quinidine, a narrow therapeutic index CYP3A4 substrate, may accumulate and increase QT prolongation risk, especially around the first doses or during cytokine release syndrome.
What this interaction means in plain words
Glofitamab and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glofitamab belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Cytokine-mediated suppression of CYP3A4 activity lowers quinidine clearance.
What to do
Monitor ECG/QTc and quinidine levels during the first treatment cycle and during CRS. Reduce the quinidine dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
Frequently asked questions
Can I take Glofitamab with Quinidine?
MediHelp rates the interaction as moderate. Glofitamab and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glofitamab induces cytokine release that can transiently suppress CYP450 enzymes. Quinidine, a narrow therapeutic index CYP3A4 substrate, may accumulate and increase QT prolongation risk, especially around the first doses or during cytokine release syndrome.
How serious is the interaction between Glofitamab and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG/QTc and quinidine levels during the first treatment cycle and during CRS. Reduce the quinidine dose if toxicity occurs.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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