Drug interactions
Glofitamab + Repaglinide
Severity: Moderate
Glofitamab and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab releases cytokines that can temporarily suppress CYP enzymes, so repaglinide levels may rise. This increases the risk of hypoglycemia.
What this interaction means in plain words
Glofitamab and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glofitamab belongs to Oncology; Repaglinide belongs to Endocrine.
Why it happens
Cytokine-mediated suppression of CYP3A4 and CYP2C8 raises repaglinide exposure.
What to do
Monitor blood glucose during the initial dosing cycles and any cytokine release syndrome. Reduce the repaglinide dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
Frequently asked questions
Can I take Glofitamab with Repaglinide?
MediHelp rates the interaction as moderate. Glofitamab and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glofitamab releases cytokines that can temporarily suppress CYP enzymes, so repaglinide levels may rise. This increases the risk of hypoglycemia.
How serious is the interaction between Glofitamab and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during the initial dosing cycles and any cytokine release syndrome. Reduce the repaglinide dose if glucose falls.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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