Drug interactions
Glofitamab + Thioridazine
Severity: Moderate
Glofitamab and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab triggers cytokine release, which can temporarily suppress CYP enzyme activity and raise exposure to sensitive substrates. Thioridazine has a narrow safety margin because higher levels increase QT prolongation and arrhythmia risk.
What this interaction means in plain words
Glofitamab and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glofitamab belongs to Oncology; Thioridazine belongs to Central Nervous System.
Why it happens
Cytokine-mediated suppression of CYP450 activity, particularly during cytokine release, reducing thioridazine clearance.
What to do
Monitor ECG and for thioridazine toxicity, especially at treatment initiation and after dose escalation when cytokine release is most likely. Consider holding or reducing thioridazine if cytokine release syndrome occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
Frequently asked questions
Can I take Glofitamab with Thioridazine?
MediHelp rates the interaction as moderate. Glofitamab and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glofitamab triggers cytokine release, which can temporarily suppress CYP enzyme activity and raise exposure to sensitive substrates. Thioridazine has a narrow safety margin because higher levels increase QT prolongation and arrhythmia risk.
How serious is the interaction between Glofitamab and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and for thioridazine toxicity, especially at treatment initiation and after dose escalation when cytokine release is most likely. Consider holding or reducing thioridazine if cytokine release syndrome occurs.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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