Drug interactions
Glofitamab + Valproic acid
Severity: Minor
Glofitamab and Valproic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab causes cytokine release that can transiently suppress CYP enzyme activity. Valproate depends only partly on CYP metabolism, so a significant effect on its exposure is unlikely.
What this interaction means in plain words
Glofitamab and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glofitamab belongs to Oncology; Valproic acid belongs to Central Nervous System.
Why it happens
Cytokine-mediated suppression of CYP enzymes during cytokine release; limited relevance to valproate.
What to do
No routine adjustment is needed. Check valproate levels or watch for toxicity if cytokine release syndrome is severe.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
Frequently asked questions
Can I take Glofitamab with Valproic acid?
MediHelp rates the interaction as minor. Glofitamab and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glofitamab causes cytokine release that can transiently suppress CYP enzyme activity. Valproate depends only partly on CYP metabolism, so a significant effect on its exposure is unlikely.
How serious is the interaction between Glofitamab and Valproic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Check valproate levels or watch for toxicity if cytokine release syndrome is severe.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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