Drug interactions
Glucagon + Indacaterol-glycopyrronium
Severity: Minor
Glucagon and Indacaterol-glycopyrronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon relaxes gastrointestinal smooth muscle, and the anticholinergic glycopyrronium also slows gut motility. Taken together, they may increase gastrointestinal effects such as constipation, bloating or ileus. Systemic exposure from inhaled glycopyrronium is low, so the effect is usually modest.
What this interaction means in plain words
Glucagon and Indacaterol-glycopyrronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glucagon belongs to Endocrine; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive inhibition of gastrointestinal motility through glucagon smooth muscle relaxation and muscarinic receptor blockade.
What to do
No routine change is needed for single-dose diagnostic glucagon; watch for abdominal distension or constipation in patients with reduced gut motility. Review the need for the combination if gastrointestinal obstruction is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Glucagon
- Atropine + Glucagon Moderate
- Benztropine + Glucagon Moderate
- Dicyclomine + Glucagon Moderate
- Diphenoxylate-atropine + Glucagon Moderate
- Glucagon + Glycopyrrolate Moderate
- Glucagon + Glycopyrronium Moderate
Frequently asked questions
Can I take Glucagon with Indacaterol-glycopyrronium?
MediHelp rates the interaction as minor. Glucagon and Indacaterol-glycopyrronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon relaxes gastrointestinal smooth muscle, and the anticholinergic glycopyrronium also slows gut motility. Taken together, they may increase gastrointestinal effects such as constipation, bloating or ileus. Systemic exposure from inhaled glycopyrronium is low, so the effect is usually modest.
How serious is the interaction between Glucagon and Indacaterol-glycopyrronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed for single-dose diagnostic glucagon; watch for abdominal distension or constipation in patients with reduced gut motility. Review the need for the combination if gastrointestinal obstruction is suspected.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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