Drug interactions
Glucagon + Labetalol
Severity: Minor
Glucagon and Labetalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon can transiently raise heart rate and blood pressure through catecholamine release, an effect that may be more pronounced in patients taking beta-blockers. Glucagon is also used to treat beta-blocker overdose because it bypasses the blocked receptors.
What this interaction means in plain words
Glucagon and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glucagon belongs to Endocrine; Labetalol belongs to Cardiovascular.
Why it happens
Glucagon stimulates cardiac cyclic AMP production independent of beta receptors and may release catecholamines, opposing beta-blockade.
What to do
Monitor pulse and blood pressure after glucagon administration in patients on labetalol. No dose change is normally needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Glucagon
- Atropine + Glucagon Moderate
- Benztropine + Glucagon Moderate
- Dicyclomine + Glucagon Moderate
- Diphenoxylate-atropine + Glucagon Moderate
- Glucagon + Glycopyrrolate Moderate
- Glucagon + Glycopyrronium Moderate
Frequently asked questions
Can I take Glucagon with Labetalol?
MediHelp rates the interaction as minor. Glucagon and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon can transiently raise heart rate and blood pressure through catecholamine release, an effect that may be more pronounced in patients taking beta-blockers. Glucagon is also used to treat beta-blocker overdose because it bypasses the blocked receptors.
How serious is the interaction between Glucagon and Labetalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pulse and blood pressure after glucagon administration in patients on labetalol. No dose change is normally needed.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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