Drug interactions
Glyburide + Posaconazole
Severity: Moderate
Glyburide and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase glyburide exposure, which can intensify its hypoglycemic effect. Glyburide has active metabolites and a long duration of action, so hypoglycemia may be severe and prolonged, especially in older or renally impaired patients.
What this interaction means in plain words
Glyburide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 and CYP2C9-mediated metabolism of glyburide by posaconazole.
What to do
Monitor blood glucose frequently and reduce the glyburide dose as needed. Consider a shorter-acting agent in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Posaconazole?
MediHelp rates the interaction as moderate. Glyburide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole may increase glyburide exposure, which can intensify its hypoglycemic effect. Glyburide has active metabolites and a long duration of action, so hypoglycemia may be severe and prolonged, especially in older or renally impaired patients.
How serious is the interaction between Glyburide and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently and reduce the glyburide dose as needed. Consider a shorter-acting agent in high-risk patients.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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