Drug interactions
Glyburide + Sotagliflozin
Severity: Moderate
Glyburide and Sotagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotagliflozin lowers blood glucose through urinary glucose loss, and combining it with a sulfonylurea such as glyburide raises the risk of hypoglycemia. The sulfonylurea effect is glucose-independent, so additive lowering can occur.
What this interaction means in plain words
Glyburide and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Sotagliflozin belongs to Endocrine.
Why it happens
Additive glucose-lowering effects, with SGLT inhibition on top of sulfonylurea-driven insulin secretion.
What to do
Consider reducing the glyburide dose when starting sotagliflozin. Monitor blood glucose and teach the patient to recognise hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Other interactions of Sotagliflozin
- Carbamazepine + Sotagliflozin Moderate
- Chlorpropamide + Sotagliflozin Moderate
- Digoxin + Sotagliflozin Moderate
- Gliclazide + Sotagliflozin Moderate
- Glimepiride-pioglitazone + Sotagliflozin Moderate
- Glimepiride + Sotagliflozin Moderate
Frequently asked questions
Can I take Glyburide with Sotagliflozin?
MediHelp rates the interaction as moderate. Glyburide and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotagliflozin lowers blood glucose through urinary glucose loss, and combining it with a sulfonylurea such as glyburide raises the risk of hypoglycemia. The sulfonylurea effect is glucose-independent, so additive lowering can occur.
How serious is the interaction between Glyburide and Sotagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glyburide dose when starting sotagliflozin. Monitor blood glucose and teach the patient to recognise hypoglycemia.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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