Drug interactions
Glycopyrrolate + Prochlorperazine
Severity: Moderate
Glycopyrrolate and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine has anticholinergic activity that adds to that of glycopyrrolate. This can cause dry mouth, constipation, urinary retention, blurred vision and tachycardia, and in susceptible patients confusion or reduced gastric motility.
What this interaction means in plain words
Glycopyrrolate and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrrolate belongs to Respiratory; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects (pharmacodynamic synergism).
What to do
Monitor for anticholinergic adverse effects, especially in older patients and those with urinary retention or glaucoma. Reduce the dose or stop one agent if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Glycopyrrolate with Prochlorperazine?
MediHelp rates the interaction as moderate. Glycopyrrolate and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prochlorperazine has anticholinergic activity that adds to that of glycopyrrolate. This can cause dry mouth, constipation, urinary retention, blurred vision and tachycardia, and in susceptible patients confusion or reduced gastric motility.
How serious is the interaction between Glycopyrrolate and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, especially in older patients and those with urinary retention or glaucoma. Reduce the dose or stop one agent if symptoms develop.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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