Drug interactions
Glycopyrrolate + Umeclidinium
Severity: Moderate
Glycopyrrolate and Umeclidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic glycopyrrolate adds antimuscarinic effects to those of inhaled umeclidinium. This may increase dry mouth, constipation, urinary retention, tachycardia and intraocular pressure.
What this interaction means in plain words
Glycopyrrolate and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrrolate belongs to Respiratory; Umeclidinium belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid concurrent long-term use when possible. Monitor for urinary retention, constipation and visual symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium
- Tiotropium + Umeclidinium Major
- Aclidinium + Umeclidinium Moderate
- Atropine iv / + Umeclidinium Moderate
- Atropine + Umeclidinium Moderate
- Belladonna alkaloids + Umeclidinium Moderate
- Bethanechol + Umeclidinium Moderate
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Glycopyrrolate with Umeclidinium?
MediHelp rates the interaction as moderate. Glycopyrrolate and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic glycopyrrolate adds antimuscarinic effects to those of inhaled umeclidinium. This may increase dry mouth, constipation, urinary retention, tachycardia and intraocular pressure.
How serious is the interaction between Glycopyrrolate and Umeclidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent long-term use when possible. Monitor for urinary retention, constipation and visual symptoms.
What other medicines interact with Umeclidinium?
MediHelp also lists interactions of Umeclidinium with, for example, Tiotropium, Aclidinium, Atropine iv /. The full list is on the Umeclidinium page.
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