Drug interactions
Glycopyrronium + Hyoscyamine
Severity: Moderate
Glycopyrronium and Hyoscyamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are antimuscarinics and their effects add together. This can cause marked dry mouth, constipation, urinary retention, tachycardia and confusion.
What this interaction means in plain words
Glycopyrronium and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrronium belongs to Respiratory; Hyoscyamine belongs to Genitourinary.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid duplicate antimuscarinic therapy where possible. Monitor for anticholinergic toxicity and lower doses if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Glycopyrronium with Hyoscyamine?
MediHelp rates the interaction as moderate. Glycopyrronium and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are antimuscarinics and their effects add together. This can cause marked dry mouth, constipation, urinary retention, tachycardia and confusion.
How serious is the interaction between Glycopyrronium and Hyoscyamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate antimuscarinic therapy where possible. Monitor for anticholinergic toxicity and lower doses if it develops.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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