Drug interactions
Glycopyrronium + Metoclopramide
Severity: Moderate
Glycopyrronium and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glycopyrrolate is an anticholinergic that slows gastrointestinal motility and directly opposes the cholinergic prokinetic effect of metoclopramide. Efficacy of metoclopramide may be reduced.
What this interaction means in plain words
Glycopyrronium and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrronium belongs to Respiratory; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Pharmacodynamic antagonism: anticholinergic inhibition of GI motility versus metoclopramide prokinetic action, with possible reduced absorption.
What to do
Avoid combining when a prokinetic effect is desired; otherwise monitor for reduced symptom control and adjust therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Glycopyrronium + Potassium chloride Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
Frequently asked questions
Can I take Glycopyrronium with Metoclopramide?
MediHelp rates the interaction as moderate. Glycopyrronium and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glycopyrrolate is an anticholinergic that slows gastrointestinal motility and directly opposes the cholinergic prokinetic effect of metoclopramide. Efficacy of metoclopramide may be reduced.
How serious is the interaction between Glycopyrronium and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining when a prokinetic effect is desired; otherwise monitor for reduced symptom control and adjust therapy.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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