Drug interactions
Glycopyrronium + Trimipramine
Severity: Moderate
Glycopyrronium and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a tricyclic antidepressant with notable anticholinergic activity, so combined use with glycopyrronium increases dry mouth, constipation, urinary retention, blurred vision and tachycardia. Older patients are particularly susceptible.
What this interaction means in plain words
Glycopyrronium and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrronium belongs to Respiratory; Trimipramine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic adverse effects and reduce doses or select an alternative if they become troublesome. Take extra care in glaucoma, prostatic hypertrophy and the elderly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Glycopyrronium with Trimipramine?
MediHelp rates the interaction as moderate. Glycopyrronium and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is a tricyclic antidepressant with notable anticholinergic activity, so combined use with glycopyrronium increases dry mouth, constipation, urinary retention, blurred vision and tachycardia. Older patients are particularly susceptible.
How serious is the interaction between Glycopyrronium and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and reduce doses or select an alternative if they become troublesome. Take extra care in glaucoma, prostatic hypertrophy and the elderly.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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