Drug interactions
Golimumab + Mycophenolate mofetil
Severity: Major
Golimumab and Mycophenolate mofetil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining mycophenolate with the TNF blocker golimumab produces additive immunosuppression and raises the risk of serious bacterial, fungal, viral and opportunistic infections. Lymphoma and other malignancy concerns may also be compounded.
What this interaction means in plain words
Golimumab and Mycophenolate mofetil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Golimumab belongs to Musculoskeletal; Mycophenolate mofetil belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic immunosuppression through lymphocyte proliferation inhibition (mycophenolate) and TNF-alpha neutralization (golimumab).
What to do
Use together only when clearly indicated, and screen for latent TB and hepatitis B before starting. Monitor closely for signs of infection and withhold therapy if a serious infection develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Golimumab with Mycophenolate mofetil?
MediHelp rates the interaction as major. Golimumab and Mycophenolate mofetil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining mycophenolate with the TNF blocker golimumab produces additive immunosuppression and raises the risk of serious bacterial, fungal, viral and opportunistic infections. Lymphoma and other malignancy concerns may also be compounded.
How serious is the interaction between Golimumab and Mycophenolate mofetil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only when clearly indicated, and screen for latent TB and hepatitis B before starting. Monitor closely for signs of infection and withhold therapy if a serious infection develops.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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