Drug interactions
Golimumab + Trastuzumab deruxtecan
Severity: Moderate
Golimumab and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan can cause neutropenia and febrile neutropenia, and golimumab impairs host defence against infection. Combined use may raise the risk and severity of infections.
What this interaction means in plain words
Golimumab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Golimumab belongs to Musculoskeletal; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive effects of chemotherapy-related myelosuppression and TNF-blocker immunosuppression.
What to do
Monitor complete blood counts and for infection signs. Consider holding golimumab during significant neutropenia or active infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Golimumab with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Golimumab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab deruxtecan can cause neutropenia and febrile neutropenia, and golimumab impairs host defence against infection. Combined use may raise the risk and severity of infections.
How serious is the interaction between Golimumab and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and for infection signs. Consider holding golimumab during significant neutropenia or active infection.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
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