Drug interactions
Goserelin + Haloperidol
Severity: Moderate
Goserelin and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with goserelin can prolong the QT interval, and haloperidol has a similar effect. Together they may increase the risk of torsades de pointes, especially in patients with other risk factors.
What this interaction means in plain words
Goserelin and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Haloperidol belongs to Central Nervous System.
Why it happens
Additive QT prolongation; androgen suppression alters cardiac repolarization while haloperidol blocks hERG potassium channels.
What to do
Check a baseline ECG and electrolytes and repeat the ECG after treatment changes. Consider an alternative to haloperidol if the QTc is markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Goserelin
Frequently asked questions
Can I take Goserelin with Haloperidol?
MediHelp rates the interaction as moderate. Goserelin and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with goserelin can prolong the QT interval, and haloperidol has a similar effect. Together they may increase the risk of torsades de pointes, especially in patients with other risk factors.
How serious is the interaction between Goserelin and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and repeat the ECG after treatment changes. Consider an alternative to haloperidol if the QTc is markedly prolonged.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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