Drug interactions
Goserelin + Hydroxyzine
Severity: Moderate
Goserelin and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is associated with QT prolongation and torsades de pointes, and androgen deprivation with goserelin may add to the effect. Risk is higher in older patients and those with heart disease or electrolyte abnormalities.
What this interaction means in plain words
Goserelin and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Hydroxyzine belongs to Respiratory.
Why it happens
Additive QT prolongation through hERG channel blockade by hydroxyzine and androgen deprivation by goserelin.
What to do
Use the lowest effective hydroxyzine dose or an alternative antihistamine in patients with QT risk factors. Check ECG and electrolytes if the combination is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Goserelin
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Goserelin with Hydroxyzine?
MediHelp rates the interaction as moderate. Goserelin and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is associated with QT prolongation and torsades de pointes, and androgen deprivation with goserelin may add to the effect. Risk is higher in older patients and those with heart disease or electrolyte abnormalities.
How serious is the interaction between Goserelin and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective hydroxyzine dose or an alternative antihistamine in patients with QT risk factors. Check ECG and electrolytes if the combination is needed.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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