Drug interactions
Goserelin + Iloperidone
Severity: Major
Goserelin and Iloperidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is an antipsychotic that prolongs the QT interval, and goserelin may contribute further. Concurrent use raises the risk of torsades de pointes.
What this interaction means in plain words
Goserelin and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Goserelin belongs to Endocrine; Iloperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation from androgen deprivation (goserelin) and antipsychotic blockade of cardiac potassium channels (iloperidone).
What to do
Check a baseline ECG and electrolytes, and monitor the QTc after combining. Consider an antipsychotic with lower QT liability if the QTc rises.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Goserelin
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Goserelin with Iloperidone?
MediHelp rates the interaction as major. Goserelin and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iloperidone is an antipsychotic that prolongs the QT interval, and goserelin may contribute further. Concurrent use raises the risk of torsades de pointes.
How serious is the interaction between Goserelin and Iloperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, and monitor the QTc after combining. Consider an antipsychotic with lower QT liability if the QTc rises.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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