Drug interactions
Goserelin + Itraconazole
Severity: Moderate
Goserelin and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with goserelin may prolong the QT interval, and itraconazole can also contribute. The combined effect is likely small but relevant in patients with cardiac risk factors.
What this interaction means in plain words
Goserelin and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Itraconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation.
What to do
Consider baseline and periodic ECG monitoring and correct electrolyte abnormalities in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Goserelin
Frequently asked questions
Can I take Goserelin with Itraconazole?
MediHelp rates the interaction as moderate. Goserelin and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with goserelin may prolong the QT interval, and itraconazole can also contribute. The combined effect is likely small but relevant in patients with cardiac risk factors.
How serious is the interaction between Goserelin and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider baseline and periodic ECG monitoring and correct electrolyte abnormalities in patients with cardiac risk factors.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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