Drug interactions
Goserelin + Osilodrostat
Severity: Moderate
Goserelin and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat is labeled for QT prolongation, and goserelin may add to it. Together they may raise arrhythmia risk, especially with hypokalemia, which osilodrostat can cause.
What this interaction means in plain words
Goserelin and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Osilodrostat belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and monitor it during therapy. Correct hypokalemia and hypomagnesemia before and during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Goserelin
Other interactions of Osilodrostat
Frequently asked questions
Can I take Goserelin with Osilodrostat?
MediHelp rates the interaction as moderate. Goserelin and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat is labeled for QT prolongation, and goserelin may add to it. Together they may raise arrhythmia risk, especially with hypokalemia, which osilodrostat can cause.
How serious is the interaction between Goserelin and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during therapy. Correct hypokalemia and hypomagnesemia before and during treatment.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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