Drug interactions
Goserelin + Osimertinib
Severity: Moderate
Goserelin and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib can prolong QTc, and goserelin may add to the effect. Combined use may increase the risk of torsades de pointes.
What this interaction means in plain words
Goserelin and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Osimertinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain periodic ECGs and electrolytes, especially in patients with heart failure or other QT risk factors. Withhold osimertinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Goserelin
Other interactions of Osimertinib
Frequently asked questions
Can I take Goserelin with Osimertinib?
MediHelp rates the interaction as moderate. Goserelin and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib can prolong QTc, and goserelin may add to the effect. Combined use may increase the risk of torsades de pointes.
How serious is the interaction between Goserelin and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain periodic ECGs and electrolytes, especially in patients with heart failure or other QT risk factors. Withhold osimertinib if QTc becomes markedly prolonged.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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