Drug interactions
Goserelin + Tacrolimus
Severity: Moderate
Goserelin and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus can prolong the QT interval, and androgen deprivation with goserelin may contribute. The combination could raise arrhythmia risk, especially when tacrolimus causes electrolyte disturbances.
What this interaction means in plain words
Goserelin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive QT prolongation from tacrolimus and goserelin-induced testosterone suppression.
What to do
Check an ECG at baseline and periodically, and monitor potassium and magnesium, correcting any abnormalities promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Goserelin
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Goserelin with Tacrolimus?
MediHelp rates the interaction as moderate. Goserelin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus can prolong the QT interval, and androgen deprivation with goserelin may contribute. The combination could raise arrhythmia risk, especially when tacrolimus causes electrolyte disturbances.
How serious is the interaction between Goserelin and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG at baseline and periodically, and monitor potassium and magnesium, correcting any abnormalities promptly.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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