Drug interactions
Goserelin + Voriconazole
Severity: Moderate
Goserelin and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy such as goserelin may prolong the QT interval, and voriconazole also has this effect. The combination can increase the risk of torsades de pointes, especially with other risk factors.
What this interaction means in plain words
Goserelin and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Additive QT interval prolongation.
What to do
Obtain a baseline ECG and monitor the QTc periodically, correcting potassium and magnesium. Reassess the combination if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Goserelin
Frequently asked questions
Can I take Goserelin with Voriconazole?
MediHelp rates the interaction as moderate. Goserelin and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy such as goserelin may prolong the QT interval, and voriconazole also has this effect. The combination can increase the risk of torsades de pointes, especially with other risk factors.
How serious is the interaction between Goserelin and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc periodically, correcting potassium and magnesium. Reassess the combination if the QTc becomes markedly prolonged.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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