Drug interactions
Granisetron + Hydroxychloroquine
Severity: Moderate
Granisetron and Hydroxychloroquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxychloroquine can prolong the QT interval, and granisetron may add a small further effect. The risk of ventricular arrhythmia rises with electrolyte problems or other QT-prolonging drugs.
What this interaction means in plain words
Granisetron and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Hydroxychloroquine belongs to Musculoskeletal.
Why it happens
Additive QT interval prolongation.
What to do
Check a baseline ECG and electrolytes, and repeat the ECG if other risk factors exist. Use an alternative antiemetic when the QTc is already prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Granisetron with Hydroxychloroquine?
MediHelp rates the interaction as moderate. Granisetron and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxychloroquine can prolong the QT interval, and granisetron may add a small further effect. The risk of ventricular arrhythmia rises with electrolyte problems or other QT-prolonging drugs.
How serious is the interaction between Granisetron and Hydroxychloroquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, and repeat the ECG if other risk factors exist. Use an alternative antiemetic when the QTc is already prolonged.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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