Drug interactions
Granisetron + Lopinavir
Severity: Moderate
Granisetron and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir is associated with QT and PR prolongation, and granisetron may add to QT effects. Ritonavir inhibits CYP3A4, which contributes to granisetron metabolism, so exposure to granisetron may rise somewhat.
What this interaction means in plain words
Granisetron and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Lopinavir belongs to Anti Virals.
Why it happens
Additive QT prolongation, with possible CYP3A4 inhibition by ritonavir raising granisetron exposure.
What to do
Check an ECG and electrolytes before starting if other QT risk factors exist. Monitor ECG during use and use the lowest effective granisetron dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Granisetron with Lopinavir?
MediHelp rates the interaction as moderate. Granisetron and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir is associated with QT and PR prolongation, and granisetron may add to QT effects. Ritonavir inhibits CYP3A4, which contributes to granisetron metabolism, so exposure to granisetron may rise somewhat.
How serious is the interaction between Granisetron and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG and electrolytes before starting if other QT risk factors exist. Monitor ECG during use and use the lowest effective granisetron dose.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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