Drug interactions
Granisetron + Midostaurin
Severity: Moderate
Granisetron and Midostaurin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midostaurin has been associated with QT prolongation, and granisetron can add to this effect. Antiemetic prophylaxis is common with midostaurin, so the pairing is likely, and risk is higher with electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Granisetron and Midostaurin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Midostaurin belongs to Oncology.
Why it happens
Additive prolongation of the QT interval.
What to do
Obtain a baseline ECG and monitor it periodically, and keep potassium and magnesium normal. Consider an antiemetic with less QT effect if the QTc rises significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Midostaurin
Frequently asked questions
Can I take Granisetron with Midostaurin?
MediHelp rates the interaction as moderate. Granisetron and Midostaurin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midostaurin has been associated with QT prolongation, and granisetron can add to this effect. Antiemetic prophylaxis is common with midostaurin, so the pairing is likely, and risk is higher with electrolyte disturbance or cardiac disease.
How serious is the interaction between Granisetron and Midostaurin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it periodically, and keep potassium and magnesium normal. Consider an antiemetic with less QT effect if the QTc rises significantly.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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