Drug interactions
Granisetron + Sevoflurane
Severity: Moderate
Granisetron and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane can prolong the QT interval during anaesthesia, and granisetron is often given perioperatively and has a modest QT effect. Combined use may add to arrhythmia risk, mainly in patients with other risk factors.
What this interaction means in plain words
Granisetron and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarisation.
What to do
Check electrolytes before surgery and monitor the ECG during anaesthesia in patients with long QT or other risk factors. Avoid additional QT-prolonging drugs in those patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Granisetron with Sevoflurane?
MediHelp rates the interaction as moderate. Granisetron and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane can prolong the QT interval during anaesthesia, and granisetron is often given perioperatively and has a modest QT effect. Combined use may add to arrhythmia risk, mainly in patients with other risk factors.
How serious is the interaction between Granisetron and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check electrolytes before surgery and monitor the ECG during anaesthesia in patients with long QT or other risk factors. Avoid additional QT-prolonging drugs in those patients.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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