Drug interactions
Granisetron + Sotalol
Severity: Major
Granisetron and Sotalol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol prolongs the QT interval in a dose-dependent manner with a well-known risk of torsades de pointes. Granisetron may add to this effect, increasing arrhythmia risk, especially with renal impairment or low potassium.
What this interaction means in plain words
Granisetron and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Granisetron belongs to Gastrointestinal Tract; Sotalol belongs to Cardiovascular.
Why it happens
Additive prolongation of cardiac repolarisation.
What to do
Avoid if possible and use an antiemetic without QT effect. If combined, monitor ECG, potassium, magnesium and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Granisetron with Sotalol?
MediHelp rates the interaction as major. Granisetron and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotalol prolongs the QT interval in a dose-dependent manner with a well-known risk of torsades de pointes. Granisetron may add to this effect, increasing arrhythmia risk, especially with renal impairment or low potassium.
How serious is the interaction between Granisetron and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use an antiemetic without QT effect. If combined, monitor ECG, potassium, magnesium and renal function.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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