Drug interactions
Granisetron + Tedizolid
Severity: Moderate
Granisetron and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tedizolid is a weak reversible MAO inhibitor, and serotonin syndrome is a theoretical concern with serotonergic drugs. Clinical data show little serotonergic effect with tedizolid, so the risk is probably low.
What this interaction means in plain words
Granisetron and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Tedizolid belongs to Anti Bacterial.
Why it happens
Theoretical additive serotonergic effect through weak MAO inhibition.
What to do
Co-administration is acceptable when needed. Monitor for signs of serotonin toxicity such as clonus, agitation and hyperthermia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Frequently asked questions
Can I take Granisetron with Tedizolid?
MediHelp rates the interaction as moderate. Granisetron and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tedizolid is a weak reversible MAO inhibitor, and serotonin syndrome is a theoretical concern with serotonergic drugs. Clinical data show little serotonergic effect with tedizolid, so the risk is probably low.
How serious is the interaction between Granisetron and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Co-administration is acceptable when needed. Monitor for signs of serotonin toxicity such as clonus, agitation and hyperthermia.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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