Drug interactions
Granisetron + Trimipramine
Severity: Moderate
Granisetron and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a tricyclic antidepressant that can prolong QT and has modest serotonergic effects. Granisetron may add to both effects, though the clinical risk is probably low.
What this interaction means in plain words
Granisetron and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Trimipramine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects and additive prolongation of cardiac repolarisation.
What to do
Monitor for serotonin toxicity and obtain an ECG if cardiac disease, electrolyte problems or other QT-prolonging drugs are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Granisetron with Trimipramine?
MediHelp rates the interaction as moderate. Granisetron and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is a tricyclic antidepressant that can prolong QT and has modest serotonergic effects. Granisetron may add to both effects, though the clinical risk is probably low.
How serious is the interaction between Granisetron and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity and obtain an ECG if cardiac disease, electrolyte problems or other QT-prolonging drugs are present.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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