Drug interactions
Granisetron + Valbenazine
Severity: Moderate
Granisetron and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine may prolong QT at higher exposures, and granisetron has a small QT effect. The combination may add to arrhythmia risk in patients with congenital long QT, bradycardia or electrolyte disturbances.
What this interaction means in plain words
Granisetron and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Valbenazine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Avoid in congenital long QT syndrome and correct electrolytes beforehand. Obtain an ECG in patients with other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Granisetron with Valbenazine?
MediHelp rates the interaction as moderate. Granisetron and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine may prolong QT at higher exposures, and granisetron has a small QT effect. The combination may add to arrhythmia risk in patients with congenital long QT, bradycardia or electrolyte disturbances.
How serious is the interaction between Granisetron and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in congenital long QT syndrome and correct electrolytes beforehand. Obtain an ECG in patients with other risk factors.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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