Drug interactions
Guanfacine + Prochlorperazine
Severity: Moderate
Guanfacine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure and cause sedation, so combined use can produce hypotension, dizziness, syncope and marked drowsiness. Older patients are particularly vulnerable to falls.
What this interaction means in plain words
Guanfacine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Guanfacine belongs to Cardiovascular; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects (central alpha-2 agonism plus peripheral alpha-blockade) and additive CNS depression.
What to do
Monitor blood pressure and heart rate, especially after starting or increasing either drug. Advise patients to rise slowly and lower the dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amiodarone + Guanfacine Moderate
- Amisulpride + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
Frequently asked questions
Can I take Guanfacine with Prochlorperazine?
MediHelp rates the interaction as moderate. Guanfacine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure and cause sedation, so combined use can produce hypotension, dizziness, syncope and marked drowsiness. Older patients are particularly vulnerable to falls.
How serious is the interaction between Guanfacine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, especially after starting or increasing either drug. Advise patients to rise slowly and lower the dose if symptomatic hypotension occurs.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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