Drug interactions
Haloperidol + Loratadine
Severity: Minor
Haloperidol and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is a CYP2D6 substrate and inhibitor and may slightly raise loratadine concentrations. Any additive sedation is generally small and the pharmacokinetic effect is unlikely to matter clinically.
What this interaction means in plain words
Haloperidol and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Haloperidol belongs to Central Nervous System; Loratadine belongs to Respiratory.
Why it happens
CYP2D6 inhibition by haloperidol reducing loratadine metabolism.
What to do
No dose adjustment is usually needed. Monitor for added sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Loratadine?
MediHelp rates the interaction as minor. Haloperidol and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Haloperidol is a CYP2D6 substrate and inhibitor and may slightly raise loratadine concentrations. Any additive sedation is generally small and the pharmacokinetic effect is unlikely to matter clinically.
How serious is the interaction between Haloperidol and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for added sedation.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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