Drug interactions
Haloperidol + Methamphetamine
Severity: Moderate
Haloperidol and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol blocks dopamine receptors and can counteract methamphetamine effects, and it also inhibits CYP2D6, which may raise methamphetamine levels. Both can influence cardiac conduction, and haloperidol can prolong the QT interval.
What this interaction means in plain words
Haloperidol and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Methamphetamine belongs to Central Nervous System.
Why it happens
Dopamine receptor antagonism opposing stimulant effects, CYP2D6 inhibition, and additive QT or cardiovascular effects.
What to do
Monitor ECG, heart rate and blood pressure in patients with cardiac risk factors, and avoid other QT-prolonging drugs. Reassess psychiatric symptoms since the stimulant may worsen psychosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Methamphetamine?
MediHelp rates the interaction as moderate. Haloperidol and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol blocks dopamine receptors and can counteract methamphetamine effects, and it also inhibits CYP2D6, which may raise methamphetamine levels. Both can influence cardiac conduction, and haloperidol can prolong the QT interval.
How serious is the interaction between Haloperidol and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and blood pressure in patients with cardiac risk factors, and avoid other QT-prolonging drugs. Reassess psychiatric symptoms since the stimulant may worsen psychosis.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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