Drug interactions
Haloperidol + Omaveloxolone
Severity: Moderate
Haloperidol and Omaveloxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone is metabolized by CYP3A4, so inhibitors can raise its levels. Haloperidol is a weak inhibitor so the increase is likely modest, but adverse effects such as liver enzyme elevation may be more likely.
What this interaction means in plain words
Haloperidol and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Omaveloxolone belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 inhibition by haloperidol reducing omaveloxolone clearance.
What to do
Monitor liver enzymes, lipids and tolerability. Reduce the omaveloxolone dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Haloperidol with Omaveloxolone?
MediHelp rates the interaction as moderate. Haloperidol and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omaveloxolone is metabolized by CYP3A4, so inhibitors can raise its levels. Haloperidol is a weak inhibitor so the increase is likely modest, but adverse effects such as liver enzyme elevation may be more likely.
How serious is the interaction between Haloperidol and Omaveloxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes, lipids and tolerability. Reduce the omaveloxolone dose if adverse effects occur.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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