Drug interactions
Haloperidol + Palbociclib
Severity: Minor
Haloperidol and Palbociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib is a CYP3A substrate, and haloperidol is at most a weak CYP3A inhibitor, so any increase in palbociclib exposure is likely small. Palbociclib may also add modest QT effects.
What this interaction means in plain words
Haloperidol and Palbociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Haloperidol belongs to Central Nervous System; Palbociclib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by haloperidol reducing palbociclib clearance.
What to do
No dose adjustment is usually required. Monitor blood counts per palbociclib monitoring routine and consider an ECG if other QT risk factors exist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Haloperidol with Palbociclib?
MediHelp rates the interaction as minor. Haloperidol and Palbociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Palbociclib is a CYP3A substrate, and haloperidol is at most a weak CYP3A inhibitor, so any increase in palbociclib exposure is likely small. Palbociclib may also add modest QT effects.
How serious is the interaction between Haloperidol and Palbociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required. Monitor blood counts per palbociclib monitoring routine and consider an ECG if other QT risk factors exist.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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