Drug interactions
Haloperidol + Ranolazine
Severity: Major
Haloperidol and Ranolazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol prolongs the QT interval and ranolazine adds to this effect, while ranolazine's weak CYP2D6 inhibition may increase haloperidol concentrations. The combination raises the risk of torsades de pointes.
What this interaction means in plain words
Haloperidol and Ranolazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Haloperidol belongs to Central Nervous System; Ranolazine belongs to Cardiovascular.
Why it happens
Additive QT prolongation, with CYP2D6 inhibition by ranolazine possibly raising haloperidol exposure.
What to do
Avoid if a safer alternative exists. If combined, obtain a baseline and follow-up ECG, correct potassium and magnesium, and use the lowest effective haloperidol dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Ranolazine?
MediHelp rates the interaction as major. Haloperidol and Ranolazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Haloperidol prolongs the QT interval and ranolazine adds to this effect, while ranolazine's weak CYP2D6 inhibition may increase haloperidol concentrations. The combination raises the risk of torsades de pointes.
How serious is the interaction between Haloperidol and Ranolazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if a safer alternative exists. If combined, obtain a baseline and follow-up ECG, correct potassium and magnesium, and use the lowest effective haloperidol dose.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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