Drug interactions
Haloperidol + Repotrectinib
Severity: Moderate
Haloperidol and Repotrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib is a CYP3A4 substrate, and haloperidol is only a weak inhibitor, so any increase in exposure is likely small. It could nonetheless add to dizziness, ataxia or other adverse effects.
What this interaction means in plain words
Haloperidol and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Repotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by haloperidol reducing repotrectinib clearance.
What to do
Monitor for neurologic adverse effects and reduce the repotrectinib dose if they occur. Prefer an antipsychotic without CYP3A4 effects if a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Haloperidol with Repotrectinib?
MediHelp rates the interaction as moderate. Haloperidol and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repotrectinib is a CYP3A4 substrate, and haloperidol is only a weak inhibitor, so any increase in exposure is likely small. It could nonetheless add to dizziness, ataxia or other adverse effects.
How serious is the interaction between Haloperidol and Repotrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurologic adverse effects and reduce the repotrectinib dose if they occur. Prefer an antipsychotic without CYP3A4 effects if a concern.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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