Drug interactions
Haloperidol + Rizatriptan
Severity: Minor
Haloperidol and Rizatriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipsychotics with serotonergic activity and triptans have been associated with serotonin syndrome in rare reports. The risk with haloperidol is low and largely theoretical, but features such as agitation, hyperthermia, and neuromuscular excitability would be significant.
What this interaction means in plain words
Haloperidol and Rizatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Haloperidol belongs to Central Nervous System; Rizatriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects (5-HT1B/1D agonism with antipsychotic receptor effects); mechanism is not well established.
What to do
No routine change is needed; advise patients to report agitation, tremor, fever, or rigidity and stop treatment if serotonin toxicity is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Haloperidol with Rizatriptan?
MediHelp rates the interaction as minor. Haloperidol and Rizatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antipsychotics with serotonergic activity and triptans have been associated with serotonin syndrome in rare reports. The risk with haloperidol is low and largely theoretical, but features such as agitation, hyperthermia, and neuromuscular excitability would be significant.
How serious is the interaction between Haloperidol and Rizatriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; advise patients to report agitation, tremor, fever, or rigidity and stop treatment if serotonin toxicity is suspected.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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