Drug interactions
Haloperidol + Rucaparib
Severity: Minor
Haloperidol and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 and other CYP enzymes, so haloperidol exposure may rise modestly. The clinical consequence is likely small but could increase extrapyramidal or QT effects.
What this interaction means in plain words
Haloperidol and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Haloperidol belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Rucaparib weakly inhibits CYP3A4 and CYP2D6, reducing haloperidol metabolism.
What to do
No routine dose change is required. Watch for extrapyramidal symptoms and sedation, and obtain an ECG if other QT-prolonging risks are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Haloperidol with Rucaparib?
MediHelp rates the interaction as minor. Haloperidol and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 and other CYP enzymes, so haloperidol exposure may rise modestly. The clinical consequence is likely small but could increase extrapyramidal or QT effects.
How serious is the interaction between Haloperidol and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required. Watch for extrapyramidal symptoms and sedation, and obtain an ECG if other QT-prolonging risks are present.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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