Drug interactions
Haloperidol + Ruxolitinib
Severity: Minor
Haloperidol and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is a weak CYP3A4 inhibitor and could modestly increase ruxolitinib exposure, with a small risk of more cytopenias. The clinical significance is likely limited.
What this interaction means in plain words
Haloperidol and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Haloperidol belongs to Central Nervous System; Ruxolitinib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4-mediated ruxolitinib metabolism by haloperidol.
What to do
No dose change is usually needed; monitor blood counts as part of routine ruxolitinib care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Haloperidol with Ruxolitinib?
MediHelp rates the interaction as minor. Haloperidol and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Haloperidol is a weak CYP3A4 inhibitor and could modestly increase ruxolitinib exposure, with a small risk of more cytopenias. The clinical significance is likely limited.
How serious is the interaction between Haloperidol and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor blood counts as part of routine ruxolitinib care.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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