Drug interactions
Haloperidol + Sevoflurane
Severity: Moderate
Haloperidol and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane and haloperidol can each prolong the QT interval. During anesthesia, this may increase the risk of torsades de pointes, especially with electrolyte disturbances.
What this interaction means in plain words
Haloperidol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Review the preoperative ECG and correct potassium and magnesium before anesthesia. Monitor the ECG continuously during and after the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Haloperidol with Sevoflurane?
MediHelp rates the interaction as moderate. Haloperidol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane and haloperidol can each prolong the QT interval. During anesthesia, this may increase the risk of torsades de pointes, especially with electrolyte disturbances.
How serious is the interaction between Haloperidol and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the preoperative ECG and correct potassium and magnesium before anesthesia. Monitor the ECG continuously during and after the procedure.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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